PS score: Genotype-phenotype comparison of human and mouse

Please use Han et al. Divergence of non-coding regulatory elements explains gene-phenotype differences between human and mouse orthologous genes. Mol Biol Evol. (2018) to cite our data. Search human or mouse genes in your interest to compare the tissue-specific transcriptome and genotype-phenotype mapping between human and mouse.

Abstract


Mice have been widely used as a model organism to investigate human gene-phenotype relationships based on a conjecture that orthologous genes generally perform similar functions and are associated with similar phenotypes. However, phenotypes associated with orthologous genes often turn out to be quite different between human and mouse. Herein, we devised a method to quantitatively compare phenotypes annotations associated with mouse models and human. Using semantic similarity comparisons, we identified orthologous genes with different phenotype annotations that were similar to comparisons of the annotation of random gene pairs. Analysis of sequence evolution and transcriptomic changes revealed that orthologous genes with phenotypic differences are correlated with changes in non-coding regulatory elements and tissue-specific expression profiles rather than changes in protein-coding sequences. To map accurate gene-phenotype relationships using model organisms, we propose that careful consideration of the evolutionary divergence of non-coding regulatory elements and transcriptomic profiles is essential.

Structural Bioinformatics Lab.